*: corresponding author, #: equal contribution


Wang Y#, Chen Z#, Davis B, Lipman W, Xing S, Zhang L, Wang T, Hafiz P, Xie W, Yan Z, Huang Z, Song J*, Bai W* (2024). Digital automation of transdermal drug delivery with high spatiotemporal resolution. Nature Communications 15(1):511. [PDF file]
Luo YJ#, Bao H#, Crowther A#, Li YD, Chen ZK, Tart DS, Asrican B, Zhang L, Song J* (2024). Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice. Cell Reports 43(5):114140. [PDF file]


Wander C#, Li YD#, Bao H, Asrican B, Luo YJ, Sullivan H, Chen Z, Zhang L, Wickersham I, Shih YY, Cohen T, Song J* (2023). Compensatory remodeling of a septo-hippocampal GABAergic network in a triple transgenic Alzheimer’s mouse model. Journal of Translational Medicine 15;21(1):258. [PDF file]
Li Y#, Luo Y#, Xie L, Tart S, Sheehy RN, Zhang L, Coleman LG, Jr, Chen X, Song J* (2023). Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease. Cell Stem Cell 30(4):415-432. [PDF file]
Li Y#, Luo Y#, Song J* (2023).Optimizing memory performance and emotional states: multi-level enhancement of adult hippocampal neurogenesis. Current Opinion in Neurobiology 79, 102693. [PDF file]
Wolter JM, Le BD, Matoba N, Lafferty MJ, Aygün N, Liang D, Courtney K,    Song J, Piven J, Zylka MJ, Stein JL (2023). Cellular genome-wide association study identifies common genetic variation influencing lithium induced neural progenitor proliferation. Biological Psychiatry 93(1):8-17.


Li Y#, Luo Y#, Chen Z, Quintanilla L, Cherasse Y, Zhang L, Lazarus M, Huang Z, Song J* (2022). Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior. Nature Neuroscience 25,630-645. [PDF file]
Quintanilla L, Su Y, Simon JM, Luo Y, Asrican B, Tart S, Sheehy RN, Li Y, Ming G, Song H, Song J* (2022). Basal forebrain cholinergic circuits orchestrate diverse cell types in the adult dentate gyrus to support neural stem cell function and spatial memory. bioRxiv. [PDF file]
Sheehy RN, Quintanilla L, Song J (2022). Epigenetic regulation in the neurogenic niche of the adult dentate gyrus. Neuroscience Letters 766, 136343.[PDF file]


Wander CM, Song J (2021). The neurogenic niche in Alzheimer's disease. Neuroscience Letters 762, 136109.[PDF file]
Asrican B*, Song J* (2021). Extracting meaningful circuit-based calcium dynamics in astrocytes and neurons from adult mouse brain slices using single-photon GCaMP imaging. Star Protocols 2(1): 100306.[PDF file]
Asrican B*, Song J* (2021). Recording membrane potential in adult neural stem cells as readout for stem cell activation following neural circuit stimulation in mouse hippocampal circuit. Star Protocols 2(1): 100335.[PDF file]


Asrican B#, Wooten J#, Li Y, Quintanilla L, Zhang F, Bao H, Yeh CY, Wander C, Luo Y, Olsen RHJ, Lim SA, Jin P, Song J* (2020). Neuropeptides modulate local astrocytes to regulate adult hippocampal neural stem cells. Neuron 108(2):349-366.[PDF file]
Li Y, Bao H, Luo Y, Yoan C, Sullivan HA, Quintanilla L, Wickersham IR, Lazarus M, Shin YY, Song J* (2020)   Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release. eLife 9:e53129.[PDF file]
Wander CM, Tsend JH, Song S, Housseiny H, Tart S, Ajit A, Shin YY, Lobrovich R, Song J, Meeker R, Irwin D, Cohen T* (2020). The accumulation of tau-immunoreactive hippocampal granules and corpora amylacea implicates reactive glia in tau pathogenesis during aging. iScience 23(7):101255. [PDF file]
Bao H, Hu Z, Lee SH, Kolagani R, Chao TH, Luo Y, Ban W, Sullivan HA, Gamero-Alameda S, Yu Y, Hsieh J, Wickersham I, Brenner SE, Shih YY, Song J* (2020). Dysregulation of hippocampal adult- born immature neurons disrupts a brain-wide network for spatial memory. bioRxiv. [PDF file]


Kang E#, Song J# (co-first author), Lin Y, Park J, Lee JH, Hussani Q, Gu Y, Ge S, Li W, Berninger B, Hsu K, Christina K, Song H, Ming GL* (2019). Interplay between a mental disorder risk gene and developmental polarity switch of GABA action leads to excitation-inhibition imbalance. Cell Reports 28(6):1419-1428. [PDF file]
Quintanilla L, Yeh CY, Bao H, Catavero C, Song J* (2019). Assaying circuit specific regulation of adult hippocampal neural precursor cells. J Vis Exp Jul 24;(149):10.3791/59237. [PDF file]


Bao H and Song J* (2018). Treating brain disorders by targeting adult neural stem cells. Trends in Molecular Medicine. 24(12): 991-1006 (Cover article; Featured article of the issue).[PDF file]
Yeh CY#, Asrican B#, Moss J, Quintanilla L, He T, Mao X, Cassé F, Gebara E, Bao H, Lu W, Toni N, Song J* (2018)  Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways. Neuron. 99(3):493-510 (Featured article, issue highlights).[PDF file]
Crowther A#, Lim SA#, Asrican B, Albright B, Wooten J, Yeh CY, Bao H, Cerri DH, Hu J, YY Ian Shin, Asokan A, Song J* (2018)  An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus. Stem Cell Reports. 10(3):1146–1159 (Cover article).[PDF file]
Chen X, Wang S, Zhou Y, Han Y, Li S, Xu Q, Xu L, Zhu Z, Deng L,Y, Yu L, Song L, Chen P, Song J, Takahashi E, He G, He L, Li W, Chen CD (2018). PHF8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway. Nature Communication 9(1):114. [PDF file]


Bao H#, Asrican B#, Li W#, Gu B, Wen ZX, Lim ZA, Haniff I, Ramakrishnan C, Deisseroth K, Philpot B, Song J* (2017) Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis.Cell Stem Cell. 21(5):604–617 (Cover article, featured article, issue highlights, recommended by F1000, selected as Best Articles in 2017 in Cell Stem Cell).[PDF file]
Catavero C, Bao H, Song J* (2017) Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis. Cell and Tissue Research. 1-14, (2017). [PDF file]
Liu K, Kim J, Zhang YS, Bao H, Denaxa M, Lim SA, Kim E, Liu C, Wickwesham IR, Pachinis V, Hatter S, Song J, Brown SP, Blackshaw S (2017) Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep. Nature. 548(7669):582-587, (2017). [PDF file]


Song J*, Olsen RHJ, Sun J, Ming GL, and Song H (2016). Neuronal circuitry mechanisms regulating adult neurogenesis. Neurogenesis, Cold Spring Harbor Press, edited by Fred Gage, Gerd Kempermann, and Hongjun Song. [PDF file]
Winkle C, Olsen RHJ, Kim H, Moy S, Song J*, Gupton S* (2016) Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory. J Neurosci. 36(18):4940-4958 (Cover article). [PDF file]
Murlidharan G, Crowther A, Reardon RA, Song J,   Asokan A (2016) Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain. JCI insights 1(14):e88034. [PDF file]


Vardy E, Robinson JE, Li C, Olsen, RHJ, DiBerto, JF, Sassano FM, Huang XP, Zhu H, Urban DJ, Rittiner JE, Crowley(Capik) NA, Song J, Kash TL, Malanga CJ, Krashes M, Roth BL (2015) A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 86(4):936-946, (2015). [PDF file]
Shin J, Berg DA, Zhu Y, Shin JY, Song J,  Bonaguidi MA,  Enikolopov G,   Nauen DW,  C hristian KM,  Ming GL, and Song H (2015). Single-cell RNA-seq with Waterfall reveals molecular cascades underlying adult neurogenesis. Cell Stem Cell  17(3):360-72. [PDF file]


A. J. Crowther, J. Song, Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny. Neuroscience Bulletin. 30(4):542-56 (2014). [PDF file]
J. Song, A.J. Crowther, R. H. J. Olsen, H. Song, G. Ming, A diametric mode of neuronal circuitry-neurogenesis coupling in the adult hippocampus via parvalbumin interneurons. Neurogenesis. 1(1), (2014). [PDF file]


M. Zhou, W. Li, S. Huang, J. Song, J. Y. Kim , X. Tian, E. Kang, C. Liu, J. Balaji, Y. Zhou, S. N. Parivash, Y. Zhou, D. Ehninger, L. He, H. Song, G. L. Ming, A. J. Silva, mTOR inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown specifically in adult-born dentate granule neurons. Neuron. 77(4):647-54 (2013). [PDF file]
J. Song, J. Sun, J. Moss, Z. Wen, G. Sun, D. Hsu, C. Zhong, H. Davoudi, K. Christian, N. Toni, G. L. Ming, H. Song, Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nature Neuroscience. 16(12):1728-30 (2013). [PDF file]
M. H. Jang, M. A. Bonaguidi, Y. Kitabatake, J. Sun, J. Song, E. Kang, H. Jun, C. Zhong, Y. Su, J. U. Guo, M. X. Wang, K. A. Sailor, J. Y. Kim, Y. Gao, K. M. Christian, G. L. Ming, H. Song, Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell Stem Cell. 12(2):215-23 (2013). [PDF file]


J. Song, K. M. Christian, G. L. Ming, H. Song, Life or death: developing cortical interneurons make their own decision. European Molecular Biology Organization Journal. 31(23):4373-4 (2012).[PDF file]
J. Song, C. Zhong, M. A. Bonaguidi, G. J. Sun, D. Hsu, Y. Gu, K. Meletis, Z. J. Huang, S. Ge, G. Enikolopov, K. Deisseroth, B. Luscher, K. M. Christian, G. L. Ming, H. Song, Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature 489(7414):150-4 (2012).[PDF file]
M. A. Bonaguidi, J. Song, G. L. Ming, H. Song, A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampus. Current Opinion in Neurobiology. 22(5):754-61 (2012).[PDF file]
D. A. Lee, J. L. Bedont, T. Pak, H. Wang, J. Song, A. Miranda-Angulo, V. Takiar, V. Charubhumi, F. Balordi, H. Takebayashi, S. Aja, E. Ford, G. Fishell, S. Blackshaw, Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nature Neuroscience 15(5):700-2 (2012).[PDF file]
J. Y. Kim, C. Y. Liu, F. Zhang, X. Duan, Z. Wen, J. Song, E. Feighery, B. Lu, D. Rujescu, D. St. Clair, K. Christian, J. H. Callicott, D. R. Weinberger, H. Song, G. L. Ming, Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell. 148(5):1051-64 (2012).[PDF file]
J. Song, K. M. Christian, G. L. Ming, H. Song, Modification of hippocampal circuitry by adult neurogenesis. Developmental Neurobiology. 72(7):1032-43 (2012).[PDF file]


J. Song, L. Parker, L. Hormozi, M. A. Tanouye, DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy. Neuroscience. 156(3):722-8 (2008).
J. Song, M. A. Tanouye, From bench to drug: human seizure modeling using Drosophila. Progress in Neurobiology. 84(2):182-91 (2008).
J. Song, M. Tanouye, Role for para sodium channel gene 3' UTR in the modification of Drosophila seizure susceptibility. Developmental Neurobiology. 67(14):1944-56 (2007).
J. Song, J. Hu, M. Tanouye, Seizure suppression by top1 mutations in Drosophila. The Journal of Neuroscience. 27(11):2927-37 (2007).
J. Song, M. A. Tanouye, Seizure suppression by shakB2, a gap junction mutation in Drosophila. Journal of Neurophysiology. 95(2):627-35 (2005).

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